Lancet 5-12-1979;1(8124):1041-1042. Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Brass EP. View abstract. J Cardiovasc Thorac Res 2020;12(4):246-255. Eur J Pediatr 1995;154:686-7. View abstract. Semin Perinatol 1999;23:152-61. View abstract. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. View abstract. ALCAR might do the same, but studies haven't confirmed this [95, 96, 97]. View abstract. Siriraj Med.J. Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. B., Karall, D., de, Klerk H., Knerr, I., Koch, H. G., Plecko, B., Roschinger, W., Schwab, K. O., Scheible, D., Wijburg, F. A., Zschocke, J., Mayatepek, E., and Wendel, U. 8588 Background: Carnitine is a natural aminoacid derivative that plays a crucial role in cellular energy metabolism. 2006;35(3):349-357. 2011;93(4):799-808. Other research reveals that acetyl-L-carnitine may also help boost brain health and function as you age (64, 65). 2005-2023 Healthline Media a Red Ventures Company. Drugs Exp Clin Res 1992;18:355-65. A., Burlina, A. Hum.Exp.Toxicol. View abstract. View abstract. 2009;32(1):E13-E19. Can Energy Drinks Cause Anxiety Attacks? - MediChannel Int J Clin Pharmacol Ther Toxicol. View abstract. View abstract. Sangouni AA, Pakravanfar F, Ghadiri-Anari A, Nadjarzadeh A, Fallahzadeh H, Hosseinzadeh M. The effect of L-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial. Information from this source is evidence-based and objective, and without commercial influence. Arch.Gerontol.Geriatr. 1988;192(4):155-157. Anemia and carnitine supplementation in hemodialyzed patients. View abstract. 2006;39(4):465-474. J Gastroenterol. 2010;14(4):498-504. Nephron 38 (1984): 120-4, 6. View abstract. View abstract. Am J Cardiol 1997;79:777-80. Integr.Cancer Ther 2007;6(1):8-13. Miwa, S. and Takikawa, O. Q. I took in the morning at about 9 but had serious trouble sleeping all night that night. 2007;52(6):1775-1776. Carnitine deficiency during valproic acid treatment. View abstract. View abstract. It can also cause a "fishy" odor of the urine, breath, and sweat. PLoS One. View abstract. 1993;15(1):1-12. Med Sci Sports Exerc. Shi, J. Caruso U, Cravotto E, Tisone G, and et al. A. View abstract. J Eur Acad Dermatol Venereol 1999;13:205-9. Interventions for treating leg ulcers in people with sickle cell disease. Long-term effects of acetyl-l-carnitine on myocardial sympathetic innervation in diabetic patients. Angiology 1995;46(8):705-713. Milio, G., Novo, G., Genova, C., Luigi, Almasio P., Novo, S., and Pinto, A. Pharmacological treatment of patients with chronic critical limb ischemia: L-propionyl-carnitine enhances the short-term effects of PGE-1. Am.J Med Genet. Lim, C. Y., Jun, D. W., Jang, S. S., Cho, W. K., Chae, J. D., and Jun, J. H. Effects of carnitine on peripheral blood mitochondrial DNA copy number and liver function in non-alcoholic fatty liver disease. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Wadzinski, J., Franks, R., Roane, D., and Bayard, M. Valproate-associated hyperammonemic encephalopathy. View abstract. View abstract. People taking carnitine have reported a number of side effects, including: Diarrhea, nausea, stomach pain, and vomiting Headaches Trouble sleeping Higher blood pressure Lower blood sugar and. View abstract. Mol.Psychiatry 2012;17(3):290-314. View abstract. 2014 May;29(5):997-1004. Sotobatake I, Noda S, Hayashi H, and et al. Available at: https://www.fda.gov/orphan/designat/alldes.rtf. J Formos.Med.Assoc. View abstract. Jacobs, P. L., Goldstein, E. R., Blackburn, W., Orem, I., and Hughes, J. J. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Am J Kidney Dis. View abstract. L-carnitine, ginseng, guarana, glucose, taurine, and more. Waldner, R., Laschan, C., Lohninger, A., Gessner, M., Tuchler, H., Huemer, M., Spiegel, W., and Karlic, H. Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma. A randomized, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. Insomnia (unable to sleep). If you've had a seizure before, you should not take carnitine. Endocr J. Am.J Clin Nutr. Micic S, Lalic N, Djordjevic D, et al. Ann Neurol 1989;26:456. Clin Ther 2012;34(8):1674-1682. Studies concerning chronic and acute effects of L-carnitine on some biological parameters in elite athletes. Does L carnitine coffee make you lose weight? 10-21-2011;17(39):4414-4420. Famularo, G., Moretti, S., Alesse, E., Trinchieri, V., Angelucci, A., Santini, G., Cifone, G., and De, Simone C. Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. View abstract. J Pediatr Gastroenterol Nutr 1985;4(5):795-798. Valcour, V., Yeh, T. M., Bartt, R., Clifford, D., Gerschenson, M., Evans, S. R., Cohen, B. J Inherit.Metab Dis 2010;33(5):555-561. 2008;15(8):595-601. View abstract. Bull.Exp.Biol.Med. Guideri, F., Acampa, M., Hayek, Y., and Zappella, M. Effects of acetyl-L-carnitine on cardiac dysautonomia in Rett syndrome: prevention of sudden death? Trovato GM, Ginardi V, Di Marco V, and et al. B., Abdenur, J. E., and Wing, D. A. Carnitine deficiency in pregnancy. View abstract. Effects of Carnitine on Thyroid Health - Thyroid Advisor 2014 Oct;84(4):821-5. View abstract. J Inherit.Metab Dis 9-10-2010; View abstract. Szymanski M, Wandtke T, Wasilow K, Andryszczyk M, Janicki R, Domaracki P. Comparison of 3- and 6-Month Outcomes of Combined Oral L-Carnitine Fumarate and Acetyl-L-Carnitine Therapy, Included in an Antioxidant Formulation, in Patients with Idiopathic Infertility. View abstract. The mitochondria act. Krahenbuhl S, Reichen J. Carnitine metabolism in patients with chronic liver disease. View abstract. Crentsil, V. Mechanistic contribution of carnitine deficiency to geriatric frailty. Pediatr Nephrol 2021;36(11):3741-3747. Roy, M. J., Dionne, S., Marx, G., Qureshi, I., Sarma, D., Levy, E., and Seidman, E. G. In vitro studies on the inhibition of colon cancer by butyrate and carnitine. 2010;30(17):1460-1463. Can L-carnitine cause insomnia? - Quora View abstract. Cardiology 2006;106(4):215-223. Pathophysiology. 2016;15:107. View abstract. View abstract. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. Wu X, Huang W, Prasad PD, et al. Ann N Y Acad Sci 2004;1033:99-107. Mayo Clin Proc. View abstract. View abstract. Reprod Biol Endocrinol 2018;16(1):5. View abstract. Gynecol Endocrinol 2021;1-5. 2010;13(2-3):148-151. View abstract. L-carnitine is supplemented daily. Guevara-Campos, J., Gonzalez-Guevara, L., Parada, Y., and Urbaez-Cano, J. Problems with Acetyl L-Carnitine? - Phoenix Rising ME/CFS Forums Mantovani G, Maccio A, Madeddu C, et al. J Androl 2012;33(2):170-175. "So there's a link . 2010;48(5):503-510. Z., and McIntyre, R. S. Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? A therapeutic alternative for hemodialysis patients. Lancet 12-13-1980;2(8207):1309-1310. Is there a good explanation for this? View abstract. A multicenter study of nutraceutical drinks for cholesterol (evaluating effectiveness and tolerability). L-carnitine supplementation may cause unpleasant fishy odor and suppress thyroid hormones. View abstract. Rockstar Energy, an energy drink company, produces Rockstar Zero Carb as well as several other Rockstar flavours. View abstract. View abstract. Changes in lipid pattern. Cardiovasc.Drugs Ther 2005;19(4):267-275. View abstract. [Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia]. In one study, people who took 3 grams every day for 21 days experienced no negative effects (57). J Am Coll Cardiol 1999;34:1618-24. Caruso U, Leone L Cravotto E Nava D. Effects of L-carnitine on anemia in aged hemodialysis patients treated with recombinant human erythropoietin: A pilot study. View abstract. Karimi, M., Mohammadi, F., Behmanesh, F., Samani, S. M., Borzouee, M., Amoozgar, H., and Haghpanah, S. Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermedia. Acta Paediatr 1995;84:93-5. Reversal of haemodialysis induced hypertriacylglycerolemia by L-carnitine. View abstract. Angelova-Fischer I, Rippke F, Fischer TW, Neufang G, Zillikens D. A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne. Various lifestyle modifications, and possibly listening to music before bed, might also help. View abstract. Insomnia; Energy drinks can cause insomnia, especially when it . View abstract. A., Thelen, J. Eur.Heart J 2007;28(5):608-612. Curr Opin Clin Nutr Metab Care 2000;3:417-24. View abstract. Kimmoun, A., Munagamage, G., Dessalles, N., Gerard, A., Feillet, F., and Levy, B. Anti-human immunodeficiency virus (HIV) activitiy, safety, and pharmacokinetics of adefovir dipivoxyl (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. Eur.J Haematol. Although not all of these side effects may occur, if they do occur they may need medical attention. Expert.Opin.Investig.Drugs 2008;17(6):827-843. L-Carnitine Side Effects | Healthfully Zanardi, R. and Smeraldi, E. A double-blind, randomised, controlled clinical trial of acetyl-L-carnitine vs. amisulpride in the treatment of dysthymia. Xue, Y. View abstract. Biogerontology. 2010;21(3):454-459. View abstract. Skip the missed dose if it is almost time for your next scheduled dose. Study carried out in septic patients of an intensive care unit. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. Yang SK, Xiao L, Song PA, Xu X, Liu FY, Sun L. Effect of L-carnitine therapy on patients in maintenance hemodialysis: a systematic review and meta-analysis. Cucinotta D, Passeri M, Ventura S, and et al. Be sure to have your blood checked regularly. J Inherit.Metab Dis 2008;31(3):361-367. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. If you do not have a dose-measuring device, ask your pharmacist for one. 2009;37(4):622-631. Carnitine in the therapy of dyslipidemic patients. 2010;28(2):127-132. Scand.J Gastroenterol. As stated previously, foods high in sugar and saturated fat have been associated with poor sleep quality and sleep disturbances . Ann.Clin Psychiatry 2009;21(4):213-236. View abstract. View abstract. Lancet 2 (1980): 763-4, 5. View abstract. Changes in physical performance of untrained volunteers: effects of L-carnitine. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. Clin Exp.Immunol. Pietropaoli, P., Caporelli, S., De Pace, F., Donati, A., Adrario, E., Luzi, A., Munch, C., Giovannini, C., and Frezzotti, A. R. [Intraoperative lactic acidosis, can it be treated? People with depression have low blood levels of a substance called acetyl-L-carnitine, according to a Stanford University School of Medicine scientist and her collaborators in a multicenter study. Ann.Saudi.Med. View abstract. Ital J Neurol Sci 1981;2(3):255-262. Am J Med 1993;95:112-3. View abstract. Cochrane.Database.Syst.Rev. View abstract. View abstract. Brass, E. P., Hoppel, C. L., and Hiatt, W. R. Effect of intravenous L-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans. Giamberardino, M. A., Dragani, L., Valente, R., di Lisa, F., Saggini, R., and Vecchiet, L. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. These symptoms are not considered to be severe side effects. View abstract. Clin Trials J 1988;25:227-237. 2003;23(5):270-277. Semeniuk, J., Shalansky, K. F., Taylor, N., Jastrzebski, J., and Cameron, E. C. Evaluation of the effect of intravenous l-carnitine on quality of life in chronic hemodialysis patients. Foods That Cause Insomnia: 10 Foods to Avoid - Verywell Health View abstract. Side Effects. Scaglia F, Longo N. Primary and secondary alterations of neonatal carnitine metabolism. Cardiovasc.Drugs Ther 1999;13:537-46. Carnitine (L-carnitine) Information | Mount Sinai - New York De Ritis G, Picardo S, Brancadoro D, and et al. View abstract. Sano M, Bell K, Cote L, et al. Prostaglandins Leukot.Essent.Fatty Acids 2002;67(1):33-38. BJU Int 2001;88:63-7.. View abstract. Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), L-carnitine deficiency. However, one analysis of nine studies mostly in obese individuals or older adults found that people lost an average of 2.9 pounds (1.3 kg) more weight while taking L-carnitine (29). 2007;44(2):83-90. Propionyl carnitine in stable effort angina. Pittler, M. H. and Ernst, E. Complementary therapies for neuropathic and neuralgic pain: systematic review. J Nutr 2007;137(3 Suppl 2):847S-849S. Huang H, Song L, Zhang H, Zhang H, Zhang J, Zhao W. Influence of L-carnitine supplementation on serum lipid profile in hemodialysis patients: a systematic review and meta-analysis. This medicine works best if you take it with a meal or within 30 minutes after a meal. 2002;2(3):240-243. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 3. Hamedi-Kalajahi F, Imani H, Mojtahedi S, Shabbidar S. Effect of L-Carnitine Supplementation on Inflammatory Markers and Serum Glucose in Hemodialysis Children: A Randomized, Placebo-Controlled Clinical Trial. Int J Clin Pharmacol Res 1990;10:355-60. View abstract. Hepatology 1997;25:148-53. View abstract. View abstract. View abstract. Evans, J. D., Jacobs, T. F., and Evans, E. W. Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy. Head, E., Nukala, V. N., Fenoglio, K. A., Muggenburg, B. According to one study, 5784% of L-carnitine is absorbed when its consumed from food, compared to only 1418% when taken as a supplement (61). J Urol. You can improve your brain health with the right diet. Rossle, C., Pichard, C., Roulet, M., Chiolero, R., Schutz, Y., Temler, E., Schindler, C., Zurlo, F., Jequier, E., and Furst, P. [Effect of L-carnitine supplemented total parenteral nutrition on postoperative lipid and nitrogen utilization]. Zhonghua Nan.Ke.Xue. L-Carnitine is a naturally occurring substance that the body needs for energy. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. For these reasons, L-carnitine supplements are only necessary in special cases, such as disease treatment. Online ahead of print. Idiopathic facial paralysis: new therapeutic prospects with acetyl-L-carnitine. El-Beshlawy, A., Youssry, I., El-Saidi, S., El, Accaoui R., Mansi, Y., Makhlouf, A., and Taher, A. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Am J Dis Child 1991;145:999-1001. Systematic review of pharmacological treatments in fragile X syndrome. View abstract. Jeulin C, Soufir JC, Marson J, et al. Effects of L-carnitine on leukocyte function and viability in hemodialysis patients: A double-blind randomized trial. By Steve Blechman BREAKING NEWS! Lancet 10-14-1978;2(8094):805-807. Nat Med. Does carnitine cause insomnia? View abstract. View abstract. Bipolar.Disord. Z., Wang, L. X., Liu, H. Z., Qi, X. W., Wang, X. H., and Ren, H. Z. L-carnitine as an adjunct therapy to percutaneous coronary intervention for non-ST elevation myocardial infarction. Int J Clin Pharmacol Res 1983;3(3):179-184. 2011;(6):CD003917. J Child Neurol 2003;18:552-4. View abstract. A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. 1996;18(1):91-96. The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study. Liu, S., Wu, H. J., Zhang, Z. Q., Chen, Q., Liu, B., Wu, J. P., and Zhu, L. L-carnitine ameliorates cancer cachexia in mice by regulating the expression and activity of carnitine palmityl transferase. 2-15-1981;96(3):263-270. View abstract. J Nephrol. Use of D,L- and L-carnitine in uraemic patients on intermittent haemodialysis. Gramignano, G., Lusso, M. R., Madeddu, C., Massa, E., Serpe, R., Deiana, L., Lamonica, G., Dessi, M., Spiga, C., Astara, G., Maccio, A., and Mantovani, G. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. J Clin Lipidology 2012;6:150-158. Andrologia 2019;51(6):e13267. View abstract. Cherchi A, Lai C, Onnis E, et al. Effect of L-carnitine on health-related quality of life in patients with liver cirrhosis. Angiology 1989;40(10):857-862. However, you should always pick the form thats best for your personal needs and goals. View abstract. Do not mix citicoline with levodopa, a medication used to treat Parkinson's disease, without talking to your doctor. This makes L-carnitine a conditionally essential nutrient (6). Sakurabayashi, T., Miyazaki, S., Yuasa, Y., Sakai, S., Suzuki, M., Takahashi, S., and Hirasawa, Y. L-carnitine supplementation decreases the left ventricular mass in patients undergoing hemodialysis. Eur.Urol. J Inherit.Metab Dis 2007;30(1):5-22. Weinhandl, E. D., Rao, M., Gilbertson, D. T., Collins, A. J., and Pereira, B. J. How Much Caffeine Is Okay? Rossignol, D. A. View abstract. Fertil.Steril. View abstract. Beneficial effects of L-carnitine in the reduction of the necrotic area in acute myocardial infarction. A., Castillo, M., Rodrigo, J. M., Aparisi, L., Serra, M. A., Wassel, A., and Bixquert, M. Effect of L-carnitine upon ammonia tolerance test in cirrhotic patients. Martinotti, G., Andreoli, S., Reina, D., Di, Nicola M., Ortolani, I., Tedeschi, D., Fanella, F., Pozzi, G., Iannoni, E., D'Iddio, S., and Prof, L. J. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Altunbasak S, Baytok V, Tasouji M, et al. Zhang, Y., Song, J. Q., Liu, P., Yan, R., Dong, J. H., Yang, Y. L., Wang, L. F., Jiang, Y. W., Zhang, Y. H., Qin, J., and Wu, X. R. [Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]. U.S. Zhang X, Cui Y, Dong L, Sun M, Zhang Y. In one review of L-carnitines safety, doses of approximately 2 grams per day appeared to be safe for long-term use. Deeks SG, Collier A, Lalezari J, et al. View abstract. AIDS Res.Hum.Retroviruses 2010;26(11):1207-1214. View abstract. What Is Carnitine Coffee? | Coffee Nerd Nutrients 2018;10(2). View abstract. La, Vignera S., Condorelli, R., Vicari, E., D'Agata, R., and Calogero, A. E. Endothelial antioxidant compound prolonged the endothelial antiapoptotic effects registered after tadalafil treatment in patients with arterial erectile dysfunction. Yet, there are a few known side effects that include agitation, insomnia and nausea. This article lists 5 natural fat burners that are supported by science. The effect of L-carnitine on insulin resistance in hemodialysed patients with chronic renal failure. Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. L-Carnitine Benefits Endurance, Fat Burning and Brain Function Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Samimi M, Jamilian M, Ebrahimi FA, Rahimi M, Tajbakhsh B, Asemi Z. Cardiovasc Drugs Ther 1998;12:291-9. South Med J 1993;86:1411-2. View abstract. 2016;17(10):970-6. View abstract. Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study. View abstract. View abstract. Int.J Vitam.Nutr.Res. (1) On top of the limitations in positive studies, it has also shown to be completely useless. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. Curr Ther Res 1980;27(2):208-216. There have been a few studies on acetyl-L-carnitine's use as a treatment. 2020;151:104554. Take the missed dose as soon as you remember. Taking too much (2 to 3 grams . Online ahead of print. You may report side effects to FDA at 1-800-FDA-1088. The effects of L-carnitine on human stamina. Effects of Citric Acid and l-Carnitine on Physical Fatigue. 2006;142(4):458-460. 12-20-2008;23(6):571-585. Marconi C, Sassi G, Carpinelli A, Cerretelli P. Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes.